Department of Materials Science and Engineering University of Ioannina School of Engineering
 
 
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PHOTO Demosthenes Fokas
Professor
Physical and Chemical Methods for the Production of Bioactive Compounds

LOCATION Administration Building, 1st floor, Office Π4
EMAIL dfokas@uoi.gr
PHONE (+30)-265100-7245 (Office)
PHONE (+30)-265100-9011 (Lab)
FAX (+30)-265100-8051
WEB Google Scholar
WEB Full CV
Academic Titles
Educational & Professional Experience
Teaching Activities in the Department
Research Interests
Representative Publications

Academic Titles
  • Diploma in Chemistry, University of Ioannina, Greece (1987)
  • Ph.D. in Chemistry, Brown University, Providence, Rhode Island, USA (1993)
Educational & Professional Experience
  • Associate Professor, Department of Materials Science and Engineering, University of Ioannina, Ioannina, Greece (2015-present).
  • Assistant Professor, Department of Materials Science and Engineering, University of Ioannina, Ioannina, Greece (2006-2015).
  • Senior Investigator, Department of Chemistry, ArQule Inc., Woburn, Massachusetts, USA (1996-2006).
  • Post-doctoral Fellow in Chemistry, Department of Chemistry, Harvard University, Cambridge, Massachusetts, USΑ (1993-1996).
  • Ph.D. Candidate, Department of Chemistry, Brown University, Providence, Rhode Island, USA (1988-1993).
Teaching Activities in the Department
  • Chemistry ΙΙ (Organic Chemistry)
  • Special Topics in Organic Chemistry
  • Introduction to Medicinal Chemistry
  • Laboratory of General Chemistry
Research Interests
  • Design and synthesis of small molecules in order to identify new chemical entities with biological properties (Lead Generation, Lead Optimization, Structure-Activity Relationship Studies).
  • Synthesis of peptide-drug conjugates for the targeted delivery of anticancer agents to cancer cells and tumors.
  • Total synthesis of bioactive natural products.
  • Synthesis of organic monomers for the preparation of novel materials
Representative Publications
  • Karanastasis, A. A.; Kenath, G, S.; Andersen, D.; Fokas, D.; Ryu, C. Y.; Ullal, C. K. One-pot surfactant-free modulation of size and functional group distribution in thermoresponsive microgels. J. Colloid Interface Sci. 2020, 568, 264-272.
  • Argyros, O.; Karampelas, T.; Varela, A.; Asvos, X.; Papakyriakou, A.; Agalou, A.; Beis, D.; Davos, C. H.; Fokas, D.; Tamvakopoulos, C. “Targeting of the Breast Cancer Microenvironment with a Potent and Linkable Oxindole Based Antiangiogenic Small Molecule”. Oncotarget 2017, 8, 37250-37262.
  • Spathis, A. D.; Asvos, X.; Ziavra, D.; Karambelas, T.; Topouzis, S.; Cournia, Z.; Qing, X.; Alexakos. P.; Smits, L.; Dalla, C.; Rideout, H.; Schwamborn, J. C.; Tamvakopoulos, C.; Fokas, D.; Vassilatis, D. K. “Nurr1:RXRα Heterodimer Activation as Monotherapy for Parkinson’s disease”. Proc. Natl. Acad. Sci. USA 2017, 114, 3999-4004.
  • Karampelas, T.; Skavatsou, E.; Argyros, O.; Fokas, D.; Tamvakopoulos, C. “GSG: A gemcitabine based peptide conjugate with improved metabolic properties and dual mode of efficacy”. Molecular Pharmaceutics 2017, 14, 674-685.
  • Argyros, O.; Karampelas, T.; Asvos, X.; Varela, A.; Sayyad, N.; Papakyriakou, A.; Davos, C. H.; Tzakos, A. G.; Fokas, D.; Tamvakopoulos, C. “Peptide–Drug Conjugate GnRH–Sunitinib Targets Angiogenesis Selectively at the Site of Action to Inhibit Tumor Growth”. Cancer Res. 2016, 76, 1181-1192.
  • Kounnis, V.; Chondrogiannis, G.; Mantzaris, M. D.; Tzakos, A. G.; Fokas, D.; Papanikolaou, N. A.; Galani, V.; Sainis, I.; Briasoulis, E. “Microcystin LR Shows Cytotoxic Activity Against Pancreatic Cancer Cells Expressing the Membrane OATP1B1 and OATP1B3 Transporters”. Anticancer Res. 2015, 35, 5857-5865.
  • Karampelas, T.; Argyros, O.; Sayyad, N.; Morgan, K.; Kolios, G.; Millar, R. P.; Tzakos, A. G.; Fokas, D.; Tamvakopoulos, C. “GnRH-Gemcitabine Conjugates for the Treatment of Androgen-Independent Prostate Cancer: Pharmacokinetic Enhancements Combined with Targeted Drug Delivery”. Bioconjugate Chem. 2014, 25, 813-823.
  • Ouzouni, M.-D.; Fokas, D.* “Synthetic Studies on Kinamycin Antibiotics: Stereoselective Synthesis of the Highly Oxygenated D-Ring and Construction of the ABD Ring System of Kinamycins”. Eur. J. Org. Chem. 2013, 6181-6189.
  • Chatziioannou, A. N.; Siskos, A. P.; Loxas, D.; Kavatzas, N.; Agrogiannis, G.; Fokas, D.; Katsiboulas, M.; Malagari, K.; Dimitriou, C. A.; Kostomitsopoulos, N.; Tsigkou, O.; Tamvakopoulos, C. “Transarterial Embolization with Sorafenib in animal livers: a pharmacokinetic study”. J. Vasc. Interv. Radiol. 2013, 24, 1657-1663.
  • Fokas, D.*; Kaselj, M.; Isome, Y.; Wang, Z. “Diversity Oriented Synthesis of a Vinblastine-Templated Library of 7-Aryl-Octahydroazonino[5,4-b]indoles via a Three-Component Reaction”. ACS Comb. Sci. 2013, 15, 49-58.
  • Kitsati, N.; Fokas, D.; Ouzouni, M.-D.; Mantzaris, M. D.; Barbouti, A.; Galaris, D. “Lipophilic Caffeic Acid Derivatives Protect Cells against H2O2-Induced DNA Damage by Chelating Intracellular Labile Iron”. J. Agr. Food Chem. 2012, 60, 7873-7879.
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